Zoledronic acid Other names: Zoledronate

Chemical formula: C₅H₁₀N₂O₇P₂  Molecular mass: 272.09 g/mol  PubChem compound: 68740

Therapeutic indications

Zoledronic acid is indicated for:

Prevention of skeletal related events

Population group: only adults (18 years old or older)

Prevention of skeletal related events (pathological fractures, spinal compression, radiation or surgery to bone, or tumour-induced hypercalcaemia) in adult patients with advanced malignancies involving bone.

For this indication, competent medicine agencies globally authorize below treatments (click for details):

Tumour-induced hypercalcaemia (TIH)

Population group: only adults (18 years old or older)

Humoral hypercalcemia of malignancy

For this indication, competent medicine agencies globally authorize below treatments (click for details):

Paget's disease of the bone

Population group: only adults (18 years old or older)

Osteitis deformans

For this indication, competent medicine agencies globally authorize below treatments (click for details):

Contraindications

Zoledronic acid is contraindicated in the following cases:

Severe renal impairment

at least one of

Renal failure stage 5: Kidney failure (GFR <15 mL/min/1.73 m2 or dialysis)

Pregnancy

Pregnancy

Lactation

Lactation

Hypocalcaemia

Hypocalcemia

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