Chemical formula: C₁₉H₂₁N₃O Molecular mass: 307.39 g/mol PubChem compound: 5732
Zolpidem is an imidazopyridine which preferentially binds the omega-1 receptor subtype (also known as the benzodiazepine-1 subtype) which corresponds to GABA-A receptors containing the alpha-1 sub-unit, whereas benzodiazepines non-selectively bind both omega-1 and omega-2 subtypes. The modulation of the chloride anion channel via this receptor leads to the specific sedative effects demonstrated by zolpidem. These effects are reversed by the benzodiazepine antagonist flumazenil.
This medicinal substance has been classified in the anatomical therapeutic chemical (ATC) classification according to its main therapeutic use as follows:
| ATC code | Group title | Classification |
|---|---|---|
| N05CF02 | Zolpidem | N Nervous system → N05 Psycholeptics → N05C Hypnotics and sedatives → N05CF Benzodiazepine related drugs |
Competent medicine agencies globally have authorized commercialization of this active ingredient according to these medication package inserts (MPIs):
| Title | Information Source | Document Type | |
|---|---|---|---|
| STILNOCT Coated tablet | Medicines & Healthcare Products Regulatory Agency (GB) | MPI, EU: SmPC | |
| AMBIEN Film-coated tablet | FDA, National Drug Code (US) | MPI, US: SPL/PLR |
Zolpidem is an active ingredient of these brands:
United States (US)
Austria (AT)Brazil (BR)
Canada (CA)
Cyprus (CY)
Estonia (EE)Finland (FI)Germany (DE)
Hong Kong (HK)Ireland (IE)Israel (IL)Japan (JP)
Lithuania (LT)Malta (MT)
Mexico (MX)
Netherlands (NL)
Poland (PL)
Romania (RO)Singapore (SG)
South Africa (ZA)Turkey (TR)United Kingdom (UK)
Note the following: The list of brand names is continuously updated, and thus does not include the total of products circulating worldwide. |
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