Chemical formula: C₈H₈N₂O₃S Molecular mass: 212.226 g/mol PubChem compound: 5734
Zonisamide is a benzisoxazole derivative with antiepileptic and anticonvulsant activity. The mechanism of action of zonisamide is not fully elucidated, but it appears to act on voltage-sensitive sodium and calcium channels, thereby disrupting synchronised neuronal firing, reducing the spread of seizure discharges and disrupting subsequent epileptic activity.
This medicinal substance has been classified in the anatomical therapeutic chemical (ATC) classification according to its main therapeutic use as follows:
| ATC code | Group title | Classification |
|---|---|---|
| N03AX15 | Zonisamide | N Nervous system → N03 Antiepileptics → N03A Antiepileptics → N03AX Other antiepileptics |
Competent medicine agencies globally have authorized commercialization of this active ingredient according to these medication package inserts (MPIs):
| Title | Information Source | Document Type | |
|---|---|---|---|
| ZONEGRAN Hard capsule | European Medicines Agency (EU) | MPI, EU: SmPC |
Zonisamide is an active ingredient of these brands:
United States (US)Australia (AU)Cyprus (CY)Estonia (EE)Finland (FI)France (FR)Ireland (IE)Italy (IT)Lithuania (LT)Netherlands (NL)Poland (PL)Romania (RO)Note the following: The list of brand names is continuously updated, and thus does not include the total of products circulating worldwide. |
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