ATC Group: C05B Antivaricose therapy

The World Health Organization's ATC classification organizes medical drugs based on therapeutic properties, chemical composition, and anatomy. It helps make essential medicines readily available globally and is widely used in the pharmaceutical industry.

Position of C05B in the ATC hierarchy

Level Code Title
1 C Cardiovascular system
2 C05 Vasoprotectives
3 C05B Antivaricose therapy

Group C05B contents

Code Title
C05BA Heparins or heparinoids for topical use
C05BB Sclerosing agents for local injection
C05BX Other sclerosing agents

Active ingredients in C05B

Active Ingredient Description
Calcium dobesilate

Calcium dobesilate is a regulator of capillary functions. Calcium dobesilate acts on the capillary walls by regulating its impaired physiological functions – increased permeability and decreased resistance. It increases erythrocyte flexibility, inhibits platelet hyperaggregation and, in diabetic retinopathy, it reduces plasma and blood hyperviscosity, thus improving blood rheological properties and tissue irrigation.

Heparin

Heparin is an anticoagulant and acts by inhibiting thrombin and by potentiating the naturally occurring inhibitors of activated Factor X (Xa).

Monoethanolamine oleate

Monoethanolamine oleate is a mild sclerosing agent indicated for the treatment of patients with esophageal varices that have recently bled, to prevent rebleeding. When injected intravenously, monoethanolamine oleate acts primarily by irritation of the intimal endothelium of the vein and produces a sterile dose-related inflammatory response. This results in fibrosis and possible occlusion of the vein.

Pentosan polysulfate

The hypothetic mechanism of action of pentosan polysulfate includes a local effect in the bladder after systemic administration and excretion into the urine by binding of glycosaminoglycans to the deficient mucous of the bladder. It is hypothesized, that a potential barrier function of pentosan polysulfate instead of the damaged urothelial mucus might play a role as well the antiinflammatory activity of pentosan polysulfate sodium.

Phenol
Polidocanol

Polidocanol has a concentration-dependent and volume-dependent damaging effect on the endothelium of blood vessels.

Sodium tetradecyl sulfate

Sodium tetradecyl sulfate is a sclerosing agent. Intravenous injection causes intima inflammation and thrombus formation. This usually occludes the injected vein. Subsequent formation of fibrous tissue results in partial or complete vein obliteration that may or may not be permanent.

Related product monographs

Title Information Source Document Type  
AETHOXYSKLEROL Solution for injection Medicines & Healthcare Products Regulatory Agency (GB) MPI, EU: SmPC
FIBROVEIN Solution for injection Medicines & Healthcare Products Regulatory Agency (GB) MPI, EU: SmPC
HIRUDOID Cream Medicines & Healthcare Products Regulatory Agency (GB) MPI, EU: SmPC
LIOTON Gel Υπουργείο Υγείας (CY) MPI, EU: SmPC
MEDORIL Capsule Υπουργείο Υγείας (CY) MPI, EU: SmPC