The World Health Organization's ATC classification organizes medical drugs based on therapeutic properties, chemical composition, and anatomy. It helps make essential medicines readily available globally and is widely used in the pharmaceutical industry.
| Level | Code | Title | |
|---|---|---|---|
1
|
C | Cardiovascular system | |
2
|
C09 | Agents acting on the renin-angiotensin system | |
3
|
C09B | ACE inhibitors, combinations | |
4
|
C09BB | ACE inhibitors and calcium channel blockers | |
5
|
C09BB04 | Perindopril and amlodipine |
| Active Ingredient |
|---|
|
Perindopril is an inhibitor of the enzyme that converts angiotensin I into angiotensin II (Angiotensin Converting Enzyme ACE). Perindopril is active in all grades of hypertension: mild, moderate, severe; a reduction in systolic and diastolic blood pressures in both supine and standing positions is observed. Amlodipine is a calcium ion influx inhibitor of the dihydropyridine group and inhibits the transmembrane influx of calcium ions into cardiac and vascular smooth muscle. The mechanism of the antihypertensive action of amlodipine is due to a direct relaxant effect on vascular smooth muscle. |
| Document | Type | Information Source | |
|---|---|---|---|
| COVERAM Tablet | MPI, EU: SmPC | Medicines Authority (MT) | |
| COVERAM Tablet | MPI, EU: SmPC | Pharmaceutical Benefits Scheme (AU) | |
| PRESTALIA Tablet | MPI, US: SPL/PLR | FDA, National Drug Code (US) | |
| REAPTAN Tablet | MPI, EU: SmPC | Pharmaceutical Benefits Scheme (AU) |
Note the following: The list of brand names is continuously updated, and thus does not include the total of products circulating worldwide.