The World Health Organization's ATC classification organizes medical drugs based on therapeutic properties, chemical composition, and anatomy. It helps make essential medicines readily available globally and is widely used in the pharmaceutical industry.
| Level | Code | Title | |
|---|---|---|---|
| 1 | D | Dermatologicals | |
| 2 | D05 | Antipsoriatics | |
| 3 | D05B | Antipsoriatics for systemic use |
| Code | Title | |
|---|---|---|
| D05BA | Psoralens for systemic use | |
| D05BB | Retinoids for treatment of psoriasis | |
| D05BX | Other antipsoriatics for systemic use |
| Active Ingredient | Description | |
|---|---|---|
| Acitretin |
Acitretin, a synthetic aromatic derivative of retinoic acid, has a favourable therapeutic ratio, with a greater and more specific inhibitory effect on psoriasis and disorders of epithelial keratinisation. The usual therapeutic response to acitretin consists of desquamation (with or without erythema) followed by more normal re-epithelialisation. Acitretin is the main active metabolite of etretinate. |
|
| Etretinate |
|
|
| Methoxsalen |
Methoxsalen, upon photoactivation, conjugates and forms covalent bonds with DNA which leads to the formation of both monofunctional (addition to a single strand of DNA) and bifunctional adducts (crosslinking of psoralen to both strands of DNA). Reactions with proteins have also been described. The formation of photoadducts results in inhibition of DNA synthesis, cell division and epidermal turnover. |
| Title | Information Source | Document Type | |
|---|---|---|---|
| OXSORALEN-ULTRA Capsule | FDA, National Drug Code (US) | MPI, US: SPL/Old | |
| SORIATANE Capsule | FDA, National Drug Code (US) | MPI, US: SPL/Old | |
| UVADEX Solution for injection | FDA, National Drug Code (US) | MPI, US: SPL/Old |
