Chemical formula: C₁₂H₈O₄ Molecular mass: 216.192 g/mol PubChem compound: 4114
Methoxsalen, upon photoactivation, conjugates and forms covalent bonds with DNA which leads to the formation of both monofunctional (addition to a single strand of DNA) and bifunctional adducts (crosslinking of psoralen to both strands of DNA). Reactions with proteins have also been described. The formation of photoadducts results in inhibition of DNA synthesis, cell division and epidermal turnover.
This medicinal substance has been classified in the anatomical therapeutic chemical (ATC) classification according to its main therapeutic use as follows:
| ATC code | Group title | Classification |
|---|---|---|
| D05AD02 | Methoxsalen | D Dermatologicals → D05 Antipsoriatics → D05A Antipsoriatics for topical use → D05AD Psoralens for topical use |
| D05BA02 | Methoxsalen | D Dermatologicals → D05 Antipsoriatics → D05B Antipsoriatics for systemic use → D05BA Psoralens for systemic use |
Methoxsalen is an active ingredient of these brands:
Australia (AU)Brazil (BR)Canada (CA)France (FR)Hong Kong (HK)Japan (JP)Malta (MT)Mexico (MX)Tunisia (TN)United Kingdom (UK)Note the following: The list of brand names is continuously updated, and thus does not include the total of products circulating worldwide. |
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