The World Health Organization's ATC classification organizes medical drugs based on therapeutic properties, chemical composition, and anatomy. It helps make essential medicines readily available globally and is widely used in the pharmaceutical industry.
| Level | Code | Title | |
|---|---|---|---|
1
|
G | Genito urinary system and sex hormones | |
2
|
G04 | Urologicals | |
3
|
G04B | Other urologicals, incl. antispasmodics | |
4
|
G04BE | Drugs used in erectile dysfunction | |
5
|
G04BE03 | Sildenafil |
The DDD is the assumed average maintenance dose per day for a drug used for its main indication in adults. The DDD is a unit of measurement and does not necessarily reflect the recommended or Prescribed Daily Dose. Therapeutic doses for individual patients and patient groups will often differ from the DDD as they will be based on individual characteristics (such as age, weight, ethnic differences, type and severity of disease) and pharmacokinetic considerations.
| Code | Route | Amount | Notes |
|---|---|---|---|
| ORAL | Oral | 50 mg |
| Active Ingredient |
|---|
|
Sildenafil is a potent and selective inhibitor of cyclic guanosine monophosphate (cGMP) specific phosphodiesterase type 5 (PDE5), the enzyme that is responsible for degradation of cGMP. Apart from the presence of this enzyme in the corpus cavernosum of the penis, PDE5 is also present in the pulmonary vasculature. Sildenafil, therefore, increases cGMP within pulmonary vascular smooth muscle cells resulting in relaxation. |
| Document | Type | Information Source | |
|---|---|---|---|
| GRANPIDAM Film-coated tablet | MPI, EU: SmPC | European Medicines Agency (EU) | |
| MYSILDECARD Film-coated tablet | MPI, EU: SmPC | European Medicines Agency (EU) | |
| REVATIO Film-coated tablet | MPI, EU: SmPC | European Medicines Agency (EU) | |
| REVATIO Solution for injection | MPI, EU: SmPC | European Medicines Agency (EU) | |
| VIAGRA Film-coated tablet | MPI, EU: SmPC | European Medicines Agency (EU) | |
| VIAGRA Film-coated tablet | MPI, US: SPL/PLR | FDA, National Drug Code (US) |
Note the following: The list of brand names is continuously updated, and thus does not include the total of products circulating worldwide.