Chemical formula: C₂₂H₃₀N₆O₄S Molecular mass: 474.576 g/mol PubChem compound: 5212
Sildenafil is a potent and selective inhibitor of cyclic guanosine monophosphate (cGMP) specific phosphodiesterase type 5 (PDE5), the enzyme that is responsible for degradation of cGMP. Apart from the presence of this enzyme in the corpus cavernosum of the penis, PDE5 is also present in the pulmonary vasculature. Sildenafil, therefore, increases cGMP within pulmonary vascular smooth muscle cells resulting in relaxation.
This medicinal substance has been classified in the anatomical therapeutic chemical (ATC) classification according to its main therapeutic use as follows:
| ATC code | Group title | Classification |
|---|---|---|
| G04BE03 | Sildenafil | G Genito urinary system and sex hormones → G04 Urologicals → G04B Other urologicals, incl. antispasmodics → G04BE Drugs used in erectile dysfunction |
Competent medicine agencies globally have authorized commercialization of this active ingredient according to these medication package inserts (MPIs):
| Title | Information Source | Document Type | |
|---|---|---|---|
| VIAGRA Film-coated tablet | European Medicines Agency (EU) | MPI, EU: SmPC | |
| REVATIO Film-coated tablet | European Medicines Agency (EU) | MPI, EU: SmPC | |
| REVATIO Solution for injection | European Medicines Agency (EU) | MPI, EU: SmPC | |
| VIAGRA Film-coated tablet | FDA, National Drug Code (US) | MPI, US: SPL/PLR |
Sildenafil is an active ingredient of these brands:
Australia (AU)
Austria (AT)
Brazil (BR)
Croatia (HR)
Cyprus (CY)Ecuador (EC)
Estonia (EE)Finland (FI)France (FR)Germany (DE)
Hong Kong (HK)
Ireland (IE)Israel (IL)Italy (IT)Lithuania (LT)
Malta (MT)Netherlands (NL)
New Zealand (NZ)Nigeria (NG)
Poland (PL)
Romania (RO)Singapore (SG)South Africa (ZA)
Spain (ES)
Tunisia (TN)Turkey (TR)
United Kingdom (UK)Note the following: The list of brand names is continuously updated, and thus does not include the total of products circulating worldwide. |
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