The World Health Organization's ATC classification organizes medical drugs based on therapeutic properties, chemical composition, and anatomy. It helps make essential medicines readily available globally and is widely used in the pharmaceutical industry.
| Level | Code | Title | |
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J | Antiinfectives for systemic use | |
2
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J01 | Antibacterials for systemic use | |
3
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J01E | Sulfonamides and trimethoprim |
| Code | Title | |
|---|---|---|
| J01EA | Trimethoprim and derivatives | |
| J01EB | Short-acting sulfonamides | |
| J01EC | Intermediate-acting sulfonamides | |
| J01ED | Long-acting sulfonamides | |
| J01EE | Combinations of sulfonamides and trimethoprim, incl. derivatives |
| Active Ingredient |
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Sulfadiazine is an antibiotic that belongs to the class of drugs known as sulphonamides. Sulfadiazine is a structural analogue and competitive antagonist of p-aminobenzoic acid preventing bacterial utilisation of PABA in the synthesis of folic acid. |
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Sulfamethoxazole competitively inhibits the utilisation of para-aminobenzoic acid in the synthesis of dihydrofolate by the bacterial cell resulting in bacteriostasis. |
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Trimethoprim is a dihydrofolate reductase inhibitor, inhibiting the conversion of bacterial dihydrofolic acid to tetrahydrofolic acid, required for the synthesis of some amino acids. Its effects are considerably greater on the cells of micro-organisms than on the mammalian cells. |
| Document | Type | Information Source | |
|---|---|---|---|
| BACTRIM DS Tablet | MPI, US: SPL/Old | FDA, National Drug Code (US) | |
| DUROBAC Tablet | MPI, Generic | Health Products Regulatory Authority (ZA) | |
| SEPTRIN Concentrate for solution for infusion | MPI, EU: SmPC | Health Products Regulatory Authority (IE) | |
| SEPTRIN Tablet | MPI, EU: SmPC | Health Products Regulatory Authority (IE) | |
| TRIMOPTIN Tablet | MPI, EU: SmPC | Health Products Regulatory Authority (IE) | |
| XEROPRIM Tablet | MPI, Generic | Marketing Authorisation Holder |