ATC Group: J01E Sulfonamides and trimethoprim

The World Health Organization's ATC classification organizes medical drugs based on therapeutic properties, chemical composition, and anatomy. It helps make essential medicines readily available globally and is widely used in the pharmaceutical industry.

Position of J01E in the ATC hierarchy

Level Code Title
1 J Antiinfectives for systemic use
2 J01 Antibacterials for systemic use
3 J01E Sulfonamides and trimethoprim

Group J01E contents

Code Title
J01EA Trimethoprim and derivatives
J01EB Short-acting sulfonamides
J01EC Intermediate-acting sulfonamides
J01ED Long-acting sulfonamides
J01EE Combinations of sulfonamides and trimethoprim, incl. derivatives

Active ingredients in J01E

Active Ingredient Description
Sulfadiazine

Sulfadiazine is an antibiotic that belongs to the class of drugs known as sulphonamides. Sulfadiazine is a structural analogue and competitive antagonist of p-aminobenzoic acid preventing bacterial utilisation of PABA in the synthesis of folic acid.

Sulfadimethoxine
Sulfadimidine
Sulfadoxine
Sulfafurazole
Sulfamethoxazole

Sulfamethoxazole competitively inhibits the utilisation of para-aminobenzoic acid in the synthesis of dihydrofolate by the bacterial cell resulting in bacteriostasis.

Sulfametrole
Sulfapyridine
Sulfathiazole
Trimethoprim

Trimethoprim is a dihydrofolate reductase inhibitor, inhibiting the conversion of bacterial dihydrofolic acid to tetrahydrofolic acid, required for the synthesis of some amino acids. Its effects are considerably greater on the cells of micro-organisms than on the mammalian cells.

Related product monographs

Title Information Source Document Type  
BACTRIM DS Tablet FDA, National Drug Code (US) MPI, US: SPL/Old
DUROBAC Tablet Health Products Regulatory Authority (ZA) MPI, Generic
SEPTRIN Concentrate for solution for infusion Health Products Regulatory Authority (IE) MPI, EU: SmPC
SEPTRIN Tablet Health Products Regulatory Authority (IE) MPI, EU: SmPC
TRIMOPTIN Tablet Health Products Regulatory Authority (IE) MPI, EU: SmPC
XEROPRIM Tablet Marketing Authorisation Holder MPI, Generic