ATC Group: L01AB Alkyl sulfonates

The World Health Organization's ATC classification organizes medical drugs based on therapeutic properties, chemical composition, and anatomy. It helps make essential medicines readily available globally and is widely used in the pharmaceutical industry.

Position of L01AB in the ATC hierarchy

Level Code Title
1 L Antineoplastic and immunomodulating agents
2 L01 Antineoplastic agents
3 L01A Alkylating agents
4 L01AB Alkyl sulfonates

Group L01AB contents

Code Title
L01AB01 Busulfan
L01AB02 Treosulfan
L01AB03 Mannosulfan

Active ingredients in L01AB

Active Ingredient Description
Busulfan

Busulfan is a potent cytotoxic agent and a bifunctional alkylating agent. In aqueous media, release of the methanesulphonate groups produces carbonium ions which can alkylate DNA, thought to be an important biological mechanism for its cytotoxic effect.

Treosulfan

Treosulfan is a prodrug of a bifunctional alkylating agent with cytotoxic activity to haematopoietic precursor cells. The activity of treosulfan is due to the spontaneous conversion into a mono-epoxide intermediate and L-diepoxybutan. Treosulfan has a broad antineoplastic and antileukaemic activity.

Related product monographs

Title Information Source Document Type  
BUSILVEX Concentrate for solution European Medicines Agency (EU) MPI, EU: SmPC
BUSULFEX Solution for injection FDA, National Drug Code (US) MPI, US: SPL/PLR
MYLERAN Film-coated tablet FDA, National Drug Code (US) MPI, US: SPL/Old
TRECONDI Powder for solution for infusion European Medicines Agency (EU) MPI, EU: SmPC