The World Health Organization's ATC classification organizes medical drugs based on therapeutic properties, chemical composition, and anatomy. It helps make essential medicines readily available globally and is widely used in the pharmaceutical industry.
Level | Code | Title | |
---|---|---|---|
1 | L | Antineoplastic and immunomodulating agents | |
2 | L01 | Antineoplastic agents | |
3 | L01A | Alkylating agents | |
4 | L01AB | Alkyl sulfonates |
Code | Title | |
---|---|---|
L01AB01 | Busulfan | |
L01AB02 | Treosulfan | |
L01AB03 | Mannosulfan |
Active Ingredient | Description | |
---|---|---|
Busulfan |
Busulfan is a potent cytotoxic agent and a bifunctional alkylating agent. In aqueous media, release of the methanesulphonate groups produces carbonium ions which can alkylate DNA, thought to be an important biological mechanism for its cytotoxic effect. |
|
Treosulfan |
Treosulfan is a prodrug of a bifunctional alkylating agent with cytotoxic activity to haematopoietic precursor cells. The activity of treosulfan is due to the spontaneous conversion into a mono-epoxide intermediate and L-diepoxybutan. Treosulfan has a broad antineoplastic and antileukaemic activity. |
Title | Information Source | Document Type | |
---|---|---|---|
BUSILVEX Concentrate for solution | European Medicines Agency (EU) | MPI, EU: SmPC | |
BUSULFAN Film-coated tablet | Medicines & Healthcare Products Regulatory Agency (GB) | MPI, EU: SmPC | |
BUSULFEX Solution for injection | FDA, National Drug Code (US) | MPI, US: SPL/PLR | |
MYLERAN Film-coated tablet | FDA, National Drug Code (US) | MPI, US: SPL/Old | |
TRECONDI Powder for solution for infusion | European Medicines Agency (EU) | MPI, EU: SmPC |