Busulfan Other names: Busulphan
Chemical formula: C₆H₁₄O₆S₂ Molecular mass: 246.302 g/mol PubChem compound: 2478
Active ingredient description
Busulfan is a potent cytotoxic agent and a bifunctional alkylating agent. In aqueous media, release of the methanesulphonate groups produces carbonium ions which can alkylate DNA, thought to be an important biological mechanism for its cytotoxic effect.
Medicine classification
This medicinal substance has been classified in the anatomical therapeutic chemical (ATC) classification according to its main therapeutic use as follows:
| ATC Group | Classification | |
|---|---|---|
| L01AB01 | Busulfan | L Antineoplastic and immunomodulating agents → L01 Antineoplastic agents → L01A Alkylating agents → L01AB Alkyl sulfonates |
Product monographs
Competent medicine agencies globally have authorized commercialization of this active ingredient according to these medication package inserts (MPIs):
| Document | Type | Information Source | |
|---|---|---|---|
| BUSULFAN Film-coated tablet | MPI, EU: SmPC | Medicines & Healthcare Products Regulatory Agency (GB) | |
| BUSILVEX Concentrate for solution | MPI, EU: SmPC | European Medicines Agency (EU) | |
| MYLERAN Film-coated tablet | MPI, US: SPL/Old | FDA, National Drug Code (US) | |
| BUSULFEX Solution for injection | MPI, US: SPL/PLR | FDA, National Drug Code (US) |
Medicines
Busulfan is an active ingredient of these brands:
Australia (AU)Austria (AT)Brazil (BR)Canada (CA)Estonia (EE)Finland (FI)France (FR)Hong Kong (HK)Ireland (IE)Israel (IL)Japan (JP)Lithuania (LT)Mexico (MX)Netherlands (NL)New Zealand (NZ)Poland (PL)Romania (RO)Singapore (SG)South Africa (ZA)Spain (ES)Tunisia (TN)Turkey (TR)United Kingdom (UK)United States (US)Note the following: The list of brand names is continuously updated, and thus does not include the total of products circulating worldwide. |
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