The World Health Organization's ATC classification organizes medical drugs based on therapeutic properties, chemical composition, and anatomy. It helps make essential medicines readily available globally and is widely used in the pharmaceutical industry.
Level | Code | Title | |
---|---|---|---|
1 | L | Antineoplastic and immunomodulating agents | |
2 | L01 | Antineoplastic agents | |
3 | L01F | Monoclonal antibodies and antibody drug conjugates | |
4 | L01FA | CD20 (Clusters of Differentiation 20) inhibitors | |
5 | L01FA02 | Ofatumumab |
Active Ingredient | Description | |
---|---|---|
Ofatumumab |
Ofatumumab is a human monoclonal antibody (IgG1) that binds specifically to a distinct epitope encompassing both the small and large extracellular loops of the CD20 molecule. The CD20 molecule is a transmembrane phosphoprotein expressed on B lymphocytes from the pre-B to mature B lymphocyte stage and on B-cell tumours. The binding of ofatumumab to the membrane-proximal epitope of the CD20 molecule induces recruitment and activation of the complement pathway at the cell surface, leading to complement dependent cytotoxicity and resultant lysis of tumour cells. |
Title | Information Source | Document Type | |
---|---|---|---|
ARZERRA Concentrate for solution for infusion | European Medicines Agency (EU) | MPI, EU: SmPC | |
KESIMPTA Solution for injection | European Medicines Agency (EU) | MPI, EU: SmPC |
Note the following: The list of brand names is continuously updated, and thus does not include the total of products circulating worldwide.