ATC Group: M01AB Acetic acid derivatives and related substances

The World Health Organization's ATC classification organizes medical drugs based on therapeutic properties, chemical composition, and anatomy. It helps make essential medicines readily available globally and is widely used in the pharmaceutical industry.

Position of M01AB in the ATC hierarchy

Level Code Title
1 M Musculo-skeletal system
2 M01 Antiinflammatory and antirheumatic products
3 M01A Antiinflammatory and antirheumatic products, non-steroids
4 M01AB Acetic acid derivatives and related substances

Group M01AB contents

Code Title
M01AB01 Indometacin
M01AB02 Sulindac
M01AB03 Tolmetin
M01AB04 Zomepirac
M01AB05 Diclofenac
M01AB06 Alclofenac
M01AB07 Bumadizone
M01AB08 Etodolac
M01AB09 Lonazolac
M01AB10 Fentiazac
M01AB11 Acemetacin
M01AB12 Difenpiramide
M01AB13 Oxametacin
M01AB14 Proglumetacin
M01AB15 Ketorolac
M01AB16 Aceclofenac
M01AB17 Bufexamac
M01AB51 Indometacin, combinations
M01AB55 Diclofenac, combinations

Active ingredients in M01AB

Active Ingredient Description
Aceclofenac

Aceclofenac is a non-steroidal agent with marked anti-inflammatory and analgesic properties. The mode of action of aceclofenac is largely based on the inhibition to prostaglandin synthesis. Aceclofenac is a potent inhibitor of the enzyme cyclo-oxygenase, which is involved in the production of prostaglandins.

Acemetacin

Acemetacin is a glycolic acid ester of indomethacin and the pharmacological activity resulting from acemetacin administration in man is derived from the presence of both acemetacin and indomethacin. The precise pharmacological mode of action of acemetacin is not known. However, unlike other NSAIDs, acemetacin is only a relatively weak inhibitor of prostaglandin synthetase.

Bumadizone
Diclofenac

Diclofenac is a non-steroidal anti-inflammatory drug. The mechanism of action of diclofenac in AK may be related to the inhibition of the cycloxygenase pathway leading to reduced prostaglandin E2 (PGE2) synthesis. In addition, immunohistochemistry (IHC) from skin biopsies ac revealed that the clinical effects of diclofenac in AK are primarily due to anti-inflammatory, anti-angiogenic and possibly anti-proliferative effects and apoptosis-inducing mechanisms.

Indometacin

Indometacin has anti-inflammatory, antipyretic, and analgesic effects, it is an inhibitor of prostaglandin synthetase.

Ketorolac

Ketorolac is a non-steroidal anti-inflammatory agent demonstrating analgesic and anti-inflammatory activity. Ketorolac inhibits the cyclo-oxygenase enzyme essential for biosynthesis of prostaglandins. Ketorolac has been shown to reduce prostaglandin levels in the aqueous humour after topical ophthalmic administration.

Proglumetacin
Sulindac

Sulindac is a fluorinated indene with a structural resemblance to indometacin. It has analgesic, anti-inflammatory and antipyretic actions.

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