The World Health Organization's ATC classification organizes medical drugs based on therapeutic properties, chemical composition, and anatomy. It helps make essential medicines readily available globally and is widely used in the pharmaceutical industry.
| Level | Code | Title | |
|---|---|---|---|
| 1 | M | Musculo-skeletal system | |
| 2 | M04 | Antigout preparations | |
| 3 | M04A | Antigout preparations | |
| 4 | M04AB | Preparations increasing uric acid excretion |
| Code | Title | |
|---|---|---|
| M04AB01 | Probenecid | |
| M04AB02 | Sulfinpyrazone | |
| M04AB03 | Benzbromarone | |
| M04AB04 | Isobromindione | |
| M04AB05 |
| Active Ingredient | Description | |
|---|---|---|
| Benzbromarone |
|
|
| Lesinurad |
Lesinurad is a selective uric acid reabsorption inhibitor that inhibits uric acid transporter URAT1. URAT1 is responsible for the majority of the reabsorption of filtered uric acid from the renal tubular lumen. By inhibiting URAT1, lesinurad increases uric acid excretion and thereby lowers serum uric acid (sUA). Lesinurad also inhibits OAT4, a uric acid transporter involved in diuretic-induced hyperuricaemia. |
|
| Probenecid |
Probenecid is a uricosuric and renal tubular blocking agent. It inhibits the tubular reabsorption of urate, thus increasing the urinary excretion of uric acid and decreasing serum urate levels. Effective uricosuria reduces the miscible urate pool, retards urate deposition, and promotes resorption of urate deposits. |
