Chemical formula: C₁₇H₁₄BrN₃O₂S Molecular mass: 404.28 g/mol PubChem compound: 53465279
Lesinurad is a selective uric acid reabsorption inhibitor that inhibits uric acid transporter URAT1. URAT1 is responsible for the majority of the reabsorption of filtered uric acid from the renal tubular lumen. By inhibiting URAT1, lesinurad increases uric acid excretion and thereby lowers serum uric acid (sUA). Lesinurad also inhibits OAT4, a uric acid transporter involved in diuretic-induced hyperuricaemia.
This medicinal substance has been classified in the anatomical therapeutic chemical (ATC) classification according to its main therapeutic use as follows:
| ATC code | Group title | Classification |
|---|---|---|
| M04AB05 | M Musculo-skeletal system → M04 Antigout preparations → M04A Antigout preparations → M04AB Preparations increasing uric acid excretion | |
Competent medicine agencies globally have authorized commercialization of this active ingredient according to these medication package inserts (MPIs):
| Title | Information Source | Document Type | |
|---|---|---|---|
| ZURAMPIC Film-coated tablet | European Medicines Agency (EU) | MPI, EU: SmPC |
Lesinurad is an active ingredient of these brands:
Brazil (BR)Note the following: The list of brand names is continuously updated, and thus does not include the total of products circulating worldwide. |
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