ATC Group: N04A Anticholinergic agents

The World Health Organization's ATC classification organizes medical drugs based on therapeutic properties, chemical composition, and anatomy. It helps make essential medicines readily available globally and is widely used in the pharmaceutical industry.

Position of N04A in the ATC hierarchy

Level Code Title
1 N Nervous system
2 N04 Anti-parkinson drugs
3 N04A Anticholinergic agents

Group N04A contents

Code Title
N04AA Tertiary amines
N04AB Ethers chemically close to antihistamines
N04AC Ethers of tropine or tropine derivatives

Active ingredients in N04A

Active Ingredient

Benzatropine possesses both anticholinergic and antihistaminic effects, although only the former have been established as therapeutically significant in the management of parkinsonism.

Biperiden is a predominantly centrally acting anti-cholinergic. It has a peripheral effect, which is low in comparison to atropine. Biperiden binds competitively to peripheral and central muscarinic receptors (primarily M1).

Orphenadrine, which is a congener of diphenhydramine without sharing its soporific effect, is an anti-muscarinic agent. Orphenadrine is used as the hydrochloride in the symptomatic treatment of Parkinsonism.

Trihexyphenidyl is an anticholinergic agent. It is an antispasmodic drug which exerts a direct inhibitory effect on the parasympathetic nervous system. It diminishes salivation, increases the heart rate, dilates the pupils and reduces spasm of smooth muscle.

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