ATC Group: R01AC Antiallergic agents, excl. corticosteroids

The World Health Organization's ATC classification organizes medical drugs based on therapeutic properties, chemical composition, and anatomy. It helps make essential medicines readily available globally and is widely used in the pharmaceutical industry.

Position of R01AC in the ATC hierarchy

Level Code Title
1 R Respiratory system
2 R01 Nasal preparations
3 R01A Decongestants and other nasal preparations for topical use
4 R01AC Antiallergic agents, excl. corticosteroids

Group R01AC contents

Code Title
R01AC01 Cromoglicic acid
R01AC02 Levocabastine
R01AC03 Azelastine
R01AC04 Antazoline
R01AC05 Spaglumic acid
R01AC06 Thonzylamine
R01AC07 Nedocromil
R01AC08 Olopatadine
R01AC51 Cromoglicic acid, combinations

Active ingredients in R01AC

Active Ingredient Description
Antazoline

Antazoline is an antagonist of histamine H1 receptors. It selectively bind to but does not activate histamine H1 receptors, thereby blocking the actions of endogenous histamine, which subsequently leads to temporary relief of the negative symptoms brought on by histamine.

Azelastine

Azelastine, a phthalazinone derivative is classified as a potent long-acting anti-allergic compound with selective H1 antagonist properties. An additional anti-inflammatory effect could be detected after topical ocular administration. Data from in vivo (pre-clinical) and in vitro studies show that azelastine inhibits the synthesis or release of the chemical mediators known to be involved in early and late stage allergic reactions e.g. leukotriene, histamine, PAF and serotonin.

Cromoglicic acid

Sodium cromoglicate (Cromoglicic acid) inhibits the activation of many of the cell types involved in the development and progression of asthma. Thus, sodium cromoglicate inhibits the release of inflammatory mediators including cytokines from mast cells and reduces the chemotactic activity of eosinophils and neutrophils.

Levocabastine

Levocabastine is a potent, fast-acting and highly selective histamine H1-antagonist with a sustained duration of action.

Nedocromil

Nedocromil is a non-steroidal agent, which has anti-inflammatory properties when administered topically in the lung. In the treatment of bronchial asthma, nedocromil sodium reduces bronchospasm, cough and bronchial hyperreactivity and improves objective measurements of lung function.

Olopatadine

Olopatadine is a potent selective antiallergic/antihistaminic agent that exerts its effects through multiple distinct mechanisms of action.

Thonzylamine

Related product monographs

Title Information Source Document Type  
NALCROM Capsule Medicines & Healthcare Products Regulatory Agency (GB) MPI, EU: SmPC
RHINOLAST Nasal spray Medicines & Healthcare Products Regulatory Agency (GB) MPI, EU: SmPC
Vividrin Eye Drops 2% sodium cromoglicate Medicines & Healthcare Products Regulatory Agency (GB) MPI, EU: SmPC
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