ATC Group: R02AB Antibiotics

The World Health Organization's ATC classification organizes medical drugs based on therapeutic properties, chemical composition, and anatomy. It helps make essential medicines readily available globally and is widely used in the pharmaceutical industry.

Position of R02AB in the ATC hierarchy

Level Code Title
1 R Respiratory system
2 R02 Throat preparations
3 R02A Throat preparations
4 R02AB Antibiotics

Group R02AB contents

Code Title
R02AB01 Neomycin
R02AB02 Tyrothricin
R02AB03 Fusafungine
R02AB04 Bacitracin
R02AB30 Gramicidin

Active ingredients in R02AB

Active Ingredient Description
Bacitracin
Fusafungine

Fusafungine is a cyclic depsipeptide antibiotic from Fusarium lateririum used for the treatment of nasal and throat infection including sinusitis, rhinitis, rhinopharyngitis, angina, laryngitis, and tracheitis. Fusafungine consists of a mixture of enniatins and showed bacteriostatic activity against a suite of microorganisms, such as Mycoplasma pneumoniae, Legionella pneumophila, Streptococcus pneumoniae, S. pyogenes, and Staphylococcus aureus, including methicillin-resistant S. aureus. Besides its bacteriostatic activity against most micro-organisms involved in respiratory tract infections fusafungine displays original anti-inflammatory properties. Fusafungine has multiple mechanisms of action, including downregulation of the expression of intercellular adhesion molecule-1 (ICAM-1) and inhibition of production of proinflammatory cytokines.

Gramicidin

Gramicidin is an antimicrobial cyclic polypeptide active in vitro against many gram positive bacteria like Bacillus subtilis and Staphylococcus aureus, but not well against gram-negative ones like E.coli.

Neomycin

Neomycin is an aminoglycoside antibiotic and acts by binding to polysomes, inhibiting protein synthesis and generating errors in the transcription of the genetic code.

Tyrothricin

Tyrothricin is a circular polypeptide with antibiotic and bacteriostatic activity. It is effective against gram-positive bacteria.

Related product monographs

Title Information Source Document Type  
NIVEMYCIN Tablets Medicines & Healthcare Products Regulatory Agency (GB) MPI, EU: SmPC