Chemical formula: C₃₃H₅₇N₃O₉ Molecular mass: 639.82 g/mol PubChem compound: 3084092
Fusafungine is a cyclic depsipeptide antibiotic from Fusarium lateririum used for the treatment of nasal and throat infection including sinusitis, rhinitis, rhinopharyngitis, angina, laryngitis, and tracheitis. Fusafungine consists of a mixture of enniatins and showed bacteriostatic activity against a suite of microorganisms, such as Mycoplasma pneumoniae, Legionella pneumophila, Streptococcus pneumoniae, S. pyogenes, and Staphylococcus aureus, including methicillin-resistant S. aureus. Besides its bacteriostatic activity against most micro-organisms involved in respiratory tract infections fusafungine displays original anti-inflammatory properties. Fusafungine has multiple mechanisms of action, including downregulation of the expression of intercellular adhesion molecule-1 (ICAM-1) and inhibition of production of proinflammatory cytokines.
This medicinal substance has been classified in the anatomical therapeutic chemical (ATC) classification according to its main therapeutic use as follows:
| ATC code | Group title | Classification |
|---|---|---|
| R02AB03 | Fusafungine | R Respiratory system → R02 Throat preparations → R02A Throat preparations → R02AB Antibiotics |
Fusafungine is an active ingredient of these brands:
Brazil (BR)Estonia (EE)Lithuania (LT)Note the following: The list of brand names is continuously updated, and thus does not include the total of products circulating worldwide. |
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