ATC Group: S01AX Other antiinfectives

The World Health Organization's ATC classification organizes medical drugs based on therapeutic properties, chemical composition, and anatomy. It helps make essential medicines readily available globally and is widely used in the pharmaceutical industry.

Position of S01AX in the ATC hierarchy

Level Code Title
1 S Sensory organs
2 S01 Ophthalmologicals
3 S01A Antiinfectives
4 S01AX Other antiinfectives

Group S01AX contents

Code Title
S01AX01 Mercury compounds
S01AX02 Silver compounds
S01AX03 Zinc compounds
S01AX04 Nitrofural
S01AX05 Bibrocathol
S01AX06 Resorcinol
S01AX07 Sodium borate
S01AX08 Hexamidine
S01AX09 Chlorhexidine
S01AX10 Sodium propionate
S01AX14 Dibrompropamidine
S01AX15 Propamidine
S01AX16 Picloxydine
S01AX18 Povidone-iodine
S01AX24

Active ingredients in S01AX

Active Ingredient Description
Bibrocathol

Bibrocathol is a bismuth-containing substance which acts as antiseptic, adstringent and secretion inhibitng agent on mucous membranes and wounds. The mechanism of action is explained by its phenolic molecular structure consisting of tetrabromopyrocatechol and bismuth hydroxide that causes the precipitation of proteins and the shrinking of superficial layers of tissue. These activities result in the formation of a protective membrane against pathogenic invasion and non-specifically inhibit inflammation and secretion.

Chlorhexidine

Chlorhexidine is an antimicrobial agent, active against a broad spectrum of Gram-positive and Gram-negative organisms, yeasts, fungi, opportunistic anaerobes and aerobes. Chlorhexidine is mainly a “membrane-acting” agent that destroys the outer membrane of the bacteria. It is inactive on bacterial spores unless the temperatures are high.

Dibrompropamidine

Dibrompropamidine is a member of the aromatic diamidine group of compounds, which possess bacteriostatic properties against a wide range of fungi and bacteria. These diamidines exert antibacterial action against pyrogenic cocci, antibiotic resistant staphylococci and some gram-negative bacilli. The activity of the diamidines is retained in the presence of organic matter such as pus and blood.

Hexamidine
Nitrofurazone
Picloxydine
Polihexanide

Polihexanide is a broad-spectrum antiseptic with excellent tolerance and a low-risk profile. The physicochemical action on the bacterial envelope prevents or impedes the development of resistant bacterial strains. Thus, polihexanide is particularly suitable and useful in the struggle against multidrug-resistant bacteria.

Povidone iodine

Povidone iodine is an iodophore that has an established use as a broad-spectrum antiseptic, mainly for the treatment of contaminated wounds and for the preoperative preparation of the skin, mucous membranes and the ocular surface. The organic complex contains approximately 10% of active available iodine. Solutions of povidone iodine gradually release iodine to exert an antimicrobial effect against bacteria, fungi, viruses, and spores. Although povidone iodine is less potent than preparations containing free iodine, it is also less toxic.

Propamidine

Propamidine is a member of the aromatic diamidine group of compounds which possess bacteriostatic properties against a wide range of organisms. These diamidines exert antibacterial action against pyrogenic cocci, antibiotic resistant staphylococci and some Gram-negative bacilli, the activity of the diamidines being retained in the presence of organic matter such as tissue fluids, pus and serum.

Sodium borate
Sodium propionate
Zinc

Zinc blocks the intestinal absorption of copper from the diet and the reabsorption of endogenously secreted copper. Zinc induces the production of metallothionein in the enterocyte, a protein that binds copper thereby preventing its transfer into the blood. The bound copper is then eliminated in the stool following desquamation of the intestinal cells.

Related product monographs

Title Information Source Document Type  
BROLENE Eye drops Medicines & Healthcare Products Regulatory Agency (GB) MPI, EU: SmPC
POSIFORLID Eye ointment Medicines Authority (MT) MPI, EU: SmPC