Polihexanide acts on both the active trophozoite and dormant cystal forms of Acanthamoeba. Polihexanide is a polycationic polymer composed of hexamethylene biguanide units and has a dual-targeted mechanism of action that involves disruption of Acanthamoeba cell membranes and DNA binding.
This medicinal substance has been classified in the anatomical therapeutic chemical (ATC) classification according to its main therapeutic use as follows:
| ATC code | Group title | Classification |
|---|---|---|
| D08AC05 | Polihexanide | D Dermatologicals → D08 Antiseptics and disinfectants → D08A Antiseptics and disinfectants → D08AC Biguanides and amidines |
| S01AX24 | S Sensory organs → S01 Ophthalmologicals → S01A Antiinfectives → S01AX Other antiinfectives | |
Competent medicine agencies globally have authorized commercialization of this active ingredient according to these medication package inserts (MPIs):
| Title | Information Source | Document Type | |
|---|---|---|---|
| AKANTIOR Eye drops | European Medicines Agency (EU) | MPI, EU: SmPC |
Polihexanide is an active ingredient of these brands:
Austria (AT)Finland (FI)Lithuania (LT)South Africa (ZA)Note the following: The list of brand names is continuously updated, and thus does not include the total of products circulating worldwide. |
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