This brand name is authorized in Austria, Croatia, Estonia, France, Italy, Lithuania, Netherlands, Poland.
The drug CORBILTA contains a combination of these active pharmaceutical ingredients (APIs):
1
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UNII
MNX7R8C5VO - CARBIDOPA
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Carbidopa is a peripheral aromatic amino acid decarboxylase inhibitor. It prevents metabolism of levodopa to dopamine in the peripheral circulation, ensuring that a higher proportion of the dose reaches the brain, where dopamine exerts its therapeutic effects. A lower dose of levodopa can be used when it is coadministered with carbidopa, reducing the incidence and severity of peripheral side effects. |
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2
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UNII
4975G9NM6T - ENTACAPONE
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Entacapone belongs to a new therapeutic class, catechol-O-methyl transferase (COMT) inhibitors. It is a reversible, specific, and mainly peripherally acting COMT inhibitor designed for concomitant administration with levodopa preparations. Entacapone prolongs the clinical response to levodopa. |
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3
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UNII
46627O600J - LEVODOPA
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According to the current understanding, the symptoms of Parkinson’s disease are related to depletion of dopamine in the corpus striatum. Dopamine does not cross the blood-brain barrier. Levodopa, the precursor of dopamine, crosses the blood brain barrier and relieves the symptoms of the disease. |
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Below package inserts are available for further reading:
| Document | Type | Information Source | |
|---|---|---|---|
| CORBILTA Film-coated tablet | MPI, EU: SmPC | European Medicines Agency (EU) |
This drug has been classified in the anatomical therapeutic chemical (ATC) classification system as follows:
| ATC Group | Classification | |
|---|---|---|
| N04BA03 | Levodopa, decarboxylase inhibitor and COMT inhibitor | N Nervous system → N04 Anti-parkinson drugs → N04B Dopaminergic agents → N04BA Dopa and dopa derivatives |
This drug has been assigned below unique identifiers within the countries it is being marketed:
| Country | Identification scheme | Identifier(s) |
|---|---|---|
| EE | Ravimiamet | 1632237, 1632248, 1632259, 1632260, 1632271, 1699780, 1699791, 1699803, 1699814, 1699825, 1699836, 1699847, 1699858, 1699869, 1699870, 1699881, 1699892, 1699904, 1699915, 1699926, 1699937, 1699948, 1699959, 1699960, 1699971, 1699982, 1699993, 1700008, 1700019, 1700020, 1700031, 1700042, 1700053, 1700064, 1700075, 1700086, 1700097 |
| FR | Base de données publique des médicaments | 67719818, 69355498 |
| IT | Agenzia del Farmaco | 043152038, 043152091, 043152141, 043152204, 043152255, 043152368 |
| LT | Valstybinė vaistų kontrolės tarnyba | 1072027, 1072028, 1072029, 1072030, 1072031, 1072032, 1072033, 1072034, 1072035, 1072036, 1072037, 1072038, 1072039, 1072040, 1072041, 1072042, 1072043, 1072044, 1072045, 1072046, 1072047, 1072048, 1072049, 1072050, 1072051, 1072052, 1072053, 1072054, 1072055, 1072056, 1072057, 1072058, 1072059, 1072060, 1072061, 1072062, 1072063, 1072064 |
| NL | Z-Index G-Standaard, PRK | 119938, 119946, 119954, 86703, 89680, 89699 |
| PL | Rejestru Produktów Leczniczych | 100311493, 100311501, 100311518, 100311524, 100311530, 100311547, 100311553 |
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