Entacapone
Chemical formula: C₁₄H₁₅N₃O₅ Molecular mass: 305.286 g/mol PubChem compound: 5281081
Active ingredient description
Entacapone belongs to a new therapeutic class, catechol-O-methyl transferase (COMT) inhibitors. It is a reversible, specific, and mainly peripherally acting COMT inhibitor designed for concomitant administration with levodopa preparations. Entacapone prolongs the clinical response to levodopa.
Medicine classification
This medicinal substance has been classified in the anatomical therapeutic chemical (ATC) classification according to its main therapeutic use as follows:
| ATC Group | Classification | |
|---|---|---|
| N04BX02 | Entacapone | N Nervous system → N04 Anti-parkinson drugs → N04B Dopaminergic agents → N04BX Other dopaminergic agents |
Product monographs
Competent medicine agencies globally have authorized commercialization of this active ingredient according to these medication package inserts (MPIs):
| Document | Type | Information Source | |
|---|---|---|---|
| COMTAN Film-coated tablet | MPI, EU: SmPC | European Medicines Agency (EU) |
Medicines
Entacapone is an active ingredient of these brands:
Australia (AU)Austria (AT)
Brazil (BR)Canada (CA)Croatia (HR)Cyprus (CY)Ecuador (EC)
Estonia (EE)Finland (FI)France (FR)Germany (DE)
Hong Kong (HK)Ireland (IE)Israel (IL)Italy (IT)Japan (JP)Lithuania (LT)Malta (MT)Mexico (MX)
Netherlands (NL)New Zealand (NZ)Poland (PL)
Romania (RO)Singapore (SG)South Africa (ZA)Spain (ES)Tunisia (TN)Turkey (TR)United Kingdom (UK)United States (US)Note the following: The list of brand names is continuously updated, and thus does not include the total of products circulating worldwide. |
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