This brand name is authorized in United States. It is also authorized in Canada.
The drug POLYTRIM contains a combination of these active pharmaceutical ingredients (APIs):
1
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UNII
19371312D4 - POLYMYXIN B SULFATE
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Polymixin B is bactericidal against a wide range of gram negative bacilli. It exerts a bactericidal effect by binding to acid phospholipids in the cell wall and membranes of the bacterium, thereby rendering ineffective the osmotic barrier normally provided by the cell membrane. |
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2
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UNII
E377MF8EQ8 - TRIMETHOPRIM SULFATE
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Trimethoprim is a dihydrofolate reductase inhibitor, inhibiting the conversion of bacterial dihydrofolic acid to tetrahydrofolic acid, required for the synthesis of some amino acids. Its effects are considerably greater on the cells of micro-organisms than on the mammalian cells. |
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This drug has been classified in the anatomical therapeutic chemical (ATC) classification system as follows:
| ATC Group | Classification | |
|---|---|---|
| S01AA30 | Combinations of different antibiotics | S Sensory organs → S01 Ophthalmologicals → S01A Antiinfectives → S01AA Antibiotics |
This drug has been assigned below unique identifiers within the countries it is being marketed:
| Country | Identification scheme | Identifier(s) |
|---|---|---|
| CA | Health Products and Food Branch | 02011956 |
| US | FDA, National Drug Code | 0023-7824 |
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