Chemical formula: C₅₆H₉₈N₁₆O₁₃ Molecular mass: 1,203.499 g/mol
Polymixin B is bactericidal against a wide range of gram negative bacilli. It exerts a bactericidal effect by binding to acid phospholipids in the cell wall and membranes of the bacterium, thereby rendering ineffective the osmotic barrier normally provided by the cell membrane.
This medicinal substance has been classified in the anatomical therapeutic chemical (ATC) classification according to its main therapeutic use as follows:
| ATC code | Group title | Classification |
|---|---|---|
| A07AA05 | Polymyxin B | A Alimentary tract and metabolism → A07 Antidiarrheals, intestinal antiinflammatory/antiinfective agents → A07A Intestinal antiinfectives → A07AA Antibiotics |
| J01XB02 | Polymyxin B | J Antiinfectives for systemic use → J01 Antibacterials for systemic use → J01X Other antibacterials → J01XB Polymyxins |
| S01AA18 | Polymyxin B | S Sensory organs → S01 Ophthalmologicals → S01A Antiinfectives → S01AA Antibiotics |
| S02AA11 | Polymyxin B | S Sensory organs → S02 Otologicals → S02A Antiinfectives → S02AA Antiinfectives |
| S03AA03 | Polymyxin B | S Sensory organs → S03 Ophthalmological and otological preparations → S03A Antiinfectives → S03AA Antiinfectives |
Competent medicine agencies globally have authorized commercialization of this active ingredient according to these medication package inserts (MPIs):
| Title | Information Source | Document Type | |
|---|---|---|---|
| POLYMYXIN B Powder for solution for injection | Health Products and Food Branch (CA) | MPI, CA: SPM |
Polymyxin B is an active ingredient of these brands:
United States (US)
Brazil (BR)
Canada (CA)
Croatia (HR)Cyprus (CY)
Ecuador (EC)
Estonia (EE)
Finland (FI)
France (FR)
Hong Kong (HK)
Ireland (IE)
Israel (IL)
Lithuania (LT)Malta (MT)Mexico (MX)
Netherlands (NL)
New Zealand (NZ)
Nigeria (NG)
Poland (PL)
Romania (RO)Singapore (SG)
South Africa (ZA)
Spain (ES)
Tunisia (TN)
Turkey (TR)United Kingdom (UK)Note the following: The list of brand names is continuously updated, and thus does not include the total of products circulating worldwide. |
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