This brand name is authorized in South Africa
The drug RIFAFOUR e-275 contains a combination of these active pharmaceutical ingredients (APIs):
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1
Rifampicin
UNII VJT6J7R4TR - RIFAMPIN
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Rifampicin is an active bactericidial antituberculosis drug which is particularly active against the rapidly growing extracellular organisms and also has bactericidial activity intracellularly. Rifampicin inhibits DNA-dependent RNA polymerase activity in susceptible cells. Specifically, it interacts with bacterial RNA polymerase but does not inhibit the mammalian enzyme. |
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2
Isoniazid
UNII V83O1VOZ8L - ISONIAZID
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Isoniazid is used mainly in the treatment of pulmonary tuberculosis but it appears to be effective also in the treatment of extrapulmonary lesions, including meningitis and genito-urinary disease. |
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3
Pyrazinamide
UNII 2KNI5N06TI - PYRAZINAMIDE
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Pyrazinamide exhibits tuberculostatic activity. Pyrazinamide is active only at an acid pH, and it is therefore active mainly on the tubercle bacilli located within the cell. |
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4
Ethambutol
UNII QE4VW5FO07 - ETHAMBUTOL HYDROCHLORIDE
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Ethambutol is bacteriostatic. It is effective against Mycobacterium tuberculosi and M.bovis with an MIC of 0.5–8µg per ml. The exact mechanism of action is unknown. While it has activity against some atypical mycobacteria including M.Kansasii, activity against other micro-organisms has not yet been reported. |
This drug has been classified in the anatomical therapeutic chemical (ATC) classification system as follows:
| ATC code | Group title | Classification |
|---|---|---|
| J04AM06 | Rifampicin, pyrazinamide, ethambutol and isoniazid | J Antiinfectives for systemic use → J04 Antimycobacterials → J04A Drugs for treatment of tuberculosis → J04AM Combinations of drugs for treatment of tuberculosis |
This drug has been assigned below unique identifiers within the countries it is being marketed:
| Country | Identification scheme | Identifier(s) |
|---|---|---|
| Country: ZA | Health Products Regulatory Authority | Identifier(s): 34/20.2.3/0187 |
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