This brand name is authorized in Australia, Germany, Ecuador, Estonia, Spain, France, Croatia, Lithuania, Mexico, Netherlands, Poland, Romania, Turkey, United States, South Africa
The drug TARKA contains a combination of these active pharmaceutical ingredients (APIs):
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1
Verapamil
UNII V3888OEY5R - VERAPAMIL HYDROCHLORIDE
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Verapamil inhibits the transmembrane influx of calcium ions into the heart and vascular smooth muscle cell. The myocardial oxygen demand is lowered directly as a result of the effect on the energy consuming metabolic processes of the myocardial cell and indirectly due to a reduction of the afterload. Due to its effect on coronary vascular smooth muscle, verapamil enhances myocardial blood flow, even in post‐stenotic areas, and relieves coronary spasms. These properties contribute to the anti‐ischaemic and antianginal efficacy of verapamil in all types of coronary artery disease. |
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2
Trandolapril
UNII 1T0N3G9CRC - TRANDOLAPRIL
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Trandolapril is a prodrug, which is rapidly, non-specifically hydrolysed to its potent, long-acting active metabolite, trandolaprilat (other metabolites are inactive) and acts as an orally-active angiotensin converting enzyme inhibitor (ACE inhibitor) without a sulphydryl group. In addition to inhibition of plasma ACE, trandolapril has been experimentally shown to inhibit tissue ACE (particularly vascular, cardial and adrenal). The clinical relevance of tissue ACE inhibition has not been established in humans. |
Below package inserts are available for further reading:
| Title | Information Source | Document Type | |
|---|---|---|---|
| TARKA Film-coated tablet | FDA, National Drug Code (US) | MPI, US: SPL/Old |
This drug has been classified in the anatomical therapeutic chemical (ATC) classification system as follows:
| ATC code | Group title | Classification |
|---|---|---|
| C09BB10 | Trandolapril and verapamil | C Cardiovascular system → C09 Agents acting on the renin-angiotensin system → C09B ACE inhibitors, combinations → C09BB ACE inhibitors and calcium channel blockers |
This drug has been assigned below unique identifiers within the countries it is being marketed:
| Country | Identification scheme | Identifier(s) |
|---|---|---|
| Country: AU | Pharmaceutical Benefits Scheme | Identifier(s): 2857J, 9387C |
| Country: DE | Bundesinstitut für Arzneimittel und Medizinprodukte | Identifier(s): 01169936, 03359486, 04127714, 04167317, 04167323, 04167346, 05484474, 05491273, 06113372, 06492257, 09687406, 09946380, 12450932 |
| Country: EC | Agencia Nacional de Regulación, Control y Vigilancia Sanitaria | Identifier(s): 29349-08-10, 5476-MEE-0920 |
| Country: EE | Ravimiamet | Identifier(s): 1233290, 1233302, 1233313, 1233324, 1233335, 1233346, 1377389, 1377390, 1377402, 1377413, 1377424, 1377435, 1377660, 1377671, 1377682, 1377693, 1377705, 1377716 |
| Country: ES | Centro de información online de medicamentos de la AEMPS | Identifier(s): 61369 |
| Country: FR | Base de données publique des médicaments | Identifier(s): 60516982, 62404028, 64603331 |
| Country: HR | Agencija za lijekove i medicinske proizvode | Identifier(s): HR-H-037957008, HR-H-738517235 |
| Country: LT | Valstybinė vaistų kontrolės tarnyba | Identifier(s): 1005320, 1005353, 1024925, 1038602, 1038603, 1059888, 1059889, 1059890, 1059891 |
| Country: MX | Comisión Federal para la Protección contra Riesgos Sanitarios | Identifier(s): 245M98 |
| Country: NL | Z-Index G-Standaard, PRK | Identifier(s): 96644 |
| Country: PL | Rejestru Produktów Leczniczych | Identifier(s): 100178278 |
| Country: RO | Agenția Națională a Medicamentului și a Dispozitivelor Medicale | Identifier(s): W68849001, W68850001, W68850002, W68850003, W68850004, W68850005, W68850006, W68850007, W68851001, W68851002, W68851003, W68851004, W68851005, W68851006, W68851007 |
| Country: TR | İlaç ve Tıbbi Cihaz Kurumu | Identifier(s): 8699548092732, 8699548093050 |
| Country: US | FDA, National Drug Code | Identifier(s): 0074-3287, 0074-3289, 0074-3290 |
| Country: ZA | Health Products Regulatory Authority | Identifier(s): 31/7.1.3/0631, A39/7.1.3/0508, A39/7.1.3/0547 |
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