Chemical formula: C₂₄H₃₄N₂O₅ Molecular mass: 430.537 g/mol PubChem compound: 5484727
Trandolapril is a prodrug, which is rapidly, non-specifically hydrolysed to its potent, long-acting active metabolite, trandolaprilat (other metabolites are inactive) and acts as an orally-active angiotensin converting enzyme inhibitor (ACE inhibitor) without a sulphydryl group. In addition to inhibition of plasma ACE, trandolapril has been experimentally shown to inhibit tissue ACE (particularly vascular, cardial and adrenal). The clinical relevance of tissue ACE inhibition has not been established in humans.
This medicinal substance has been classified in the anatomical therapeutic chemical (ATC) classification according to its main therapeutic use as follows:
| ATC code | Group title | Classification |
|---|---|---|
| C09AA10 | Trandolapril | C Cardiovascular system → C09 Agents acting on the renin-angiotensin system → C09A ACE inhibitors, plain → C09AA ACE inhibitors, plain |
Competent medicine agencies globally have authorized commercialization of this active ingredient according to these medication package inserts (MPIs):
| Title | Information Source | Document Type | |
|---|---|---|---|
| TRANDOLAPRIL Capsule | Medicines & Healthcare Products Regulatory Agency (GB) | MPI, EU: SmPC | |
| ODRIK Hard capsule | Health Products Regulatory Authority (IE) | MPI, EU: SmPC |
Trandolapril is an active ingredient of these brands:
United States (US)
Albania (AL)
Canada (CA)Ecuador (EC)
Ireland (IE)Italy (IT)Japan (JP)Mexico (MX)
Netherlands (NL)
Tunisia (TN)Note the following: The list of brand names is continuously updated, and thus does not include the total of products circulating worldwide. |
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