Chemical formula: C₂₇H₃₈N₂O₄ Molecular mass: 454.602 g/mol PubChem compound: 2520
Verapamil inhibits the transmembrane influx of calcium ions into the heart and vascular smooth muscle cell. The myocardial oxygen demand is lowered directly as a result of the effect on the energy consuming metabolic processes of the myocardial cell and indirectly due to a reduction of the afterload. Due to its effect on coronary vascular smooth muscle, verapamil enhances myocardial blood flow, even in post‐stenotic areas, and relieves coronary spasms. These properties contribute to the anti‐ischaemic and antianginal efficacy of verapamil in all types of coronary artery disease.
This medicinal substance has been classified in the anatomical therapeutic chemical (ATC) classification according to its main therapeutic use as follows:
| ATC code | Group title | Classification |
|---|---|---|
| C08DA01 | Verapamil | C Cardiovascular system → C08 Calcium channel blockers → C08D Selective calcium channel blockers with direct cardiac effects → C08DA Phenylalkylamine derivatives |
Competent medicine agencies globally have authorized commercialization of this active ingredient according to these medication package inserts (MPIs):
| Title | Information Source | Document Type | |
|---|---|---|---|
| ISOPTIN Film‐coated tablet | Health Products Regulatory Authority (IE) | MPI, EU: SmPC | |
| VERAPAMIL Oral solution | Medicines & Healthcare Products Regulatory Agency (GB) | MPI, EU: SmPC | |
| ISOPTIN Solution for injection / infusion | Health Products Regulatory Authority (IE) | MPI, EU: SmPC | |
| SECURON Solution for injection | Medicines & Healthcare Products Regulatory Agency (GB) | MPI, EU: SmPC | |
| SECURON SR Modified-release tablet | Medicines & Healthcare Products Regulatory Agency (GB) | MPI, EU: SmPC |
Verapamil is an active ingredient of these brands:
United States (US)Australia (AU)Austria (AT)
Canada (CA)
Ecuador (EC)
Estonia (EE)Germany (DE)Hong Kong (HK)
Italy (IT)
Japan (JP)
Poland (PL)Romania (RO)South Africa (ZA)Tunisia (TN)
Turkey (TR)United Kingdom (UK)
Note the following: The list of brand names is continuously updated, and thus does not include the total of products circulating worldwide. |
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