This brand name is authorized in Lithuania
The drug TOLIRASIM contains a combination of these active pharmaceutical ingredients (APIs):
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1
Lisinopril
UNII E7199S1YWR - LISINOPRIL
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Lisinopril is a peptidyl dipeptidase inhibitor. It inhibits the angiotensin-converting enzyme (ACE) that catalyses the conversion of angiotensin I to the vasoconstrictor peptide, angiotensin II. Angiotensin II also stimulates aldosterone secretion by the adrenal cortex. Inhibition of ACE results in decreased concentrations of angiotensin II which results in decreased vasopressor activity and reduced aldosterone secretion. |
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2
Torasemide
UNII W31X2H97FB - TORSEMIDE
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Torasemide is a loop diuretic. Torasemide acts as a salidiuretic by inhibition of renal sodium and chloride reabsorption in the ascending limb of the loop of Henle. Torasemide leads to a gentle removal of edema and especially to an improvement of the working condition of the heart failure by reducing the preload and afterload. In patients with severe to endstage chronic renal failure there is a reduction of aterial blood pressure in addition to removal of edema and maintenance of residual diuresis. |
This drug has been classified in the anatomical therapeutic chemical (ATC) classification system as follows:
| ATC code | Group title | Classification |
|---|---|---|
| C09BA03 | Lisinopril and diuretics | C Cardiovascular system → C09 Agents acting on the renin-angiotensin system → C09B ACE inhibitors, combinations → C09BA ACE inhibitors and diuretics |
This drug has been assigned below unique identifiers within the countries it is being marketed:
| Country | Identification scheme | Identifier(s) |
|---|---|---|
| Country: LT | Valstybinฤ vaistลณ kontrolฤs tarnyba | Identifier(s): 1084646, 1084647, 1084648, 1084649, 1084650, 1084651, 1084652, 1084653, 1084654, 1084655, 1084656, 1084657 |
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