Refractory unstable angina pectoris

Active Ingredient: Glyceryl trinitrate

Indication for Glyceryl trinitrate

Population group: only adults (18 years old or older)

For this indication, competent medicine agencies globally authorize below treatments:

10-20 micrograms/minute

Route of admnistration

Intravenous

Defined daily dose

10 - 20 ug

Dosage regimen

From 10 To 20 ug once every day

Detailed description

An initial infusion rate of 10-15 micrograms/minute is recommended; this may be increased cautiously in increments of 5-10 micrograms until either relief of angina is achieved, headache prevents further increase in dose, or the mean arterial pressure falls by more than 20 mmHg.

Active ingredient

Glyceryl trinitrate

Glyceryl trinitrate is a vasodilator and is used for angina of effort. Vasodilation is achieved by the releasing of free redical nitric oxide which activates guanylate cyclase and increases synthesis of guanosine 3′ and 5′-monophosphate with resultant effects on the phosphorylation of proteins in smooth muscle. If taken in excess, its vasodilatory effect can cause headache.

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