Chemical formula: C₃H₅N₃O₉ Molecular mass: 227.087 g/mol PubChem compound: 4510
Glyceryl trinitrate is a vasodilator and is used for angina of effort. Vasodilation is achieved by the releasing of free redical nitric oxide which activates guanylate cyclase and increases synthesis of guanosine 3′ and 5′-monophosphate with resultant effects on the phosphorylation of proteins in smooth muscle. If taken in excess, its vasodilatory effect can cause headache.
This medicinal substance has been classified in the anatomical therapeutic chemical (ATC) classification according to its main therapeutic use as follows:
| ATC code | Group title | Classification |
|---|---|---|
| C01DA02 | Glyceryl trinitrate | C Cardiovascular system → C01 Cardiac therapy → C01D Vasodilators used in cardiac diseases → C01DA Organic nitrates |
| C05AE01 | Glyceryl trinitrate | C Cardiovascular system → C05 Vasoprotectives → C05A Agents for treatment of hemorrhoids and anal fissures for topical use → C05AE Muscle relaxants |
Competent medicine agencies globally have authorized commercialization of this active ingredient according to these medication package inserts (MPIs):
| Title | Information Source | Document Type | |
|---|---|---|---|
| NITRONAL Solution for infusion | Medicines & Healthcare Products Regulatory Agency (GB) | MPI, EU: SmPC | |
| PERCUTOL Ointment | Medicines & Healthcare Products Regulatory Agency (GB) | MPI, EU: SmPC | |
| MINITRAN 5 Adhesive transdermal patch | Medicines & Healthcare Products Regulatory Agency (GB) | MPI, EU: SmPC | |
| RECTOGESIC Rectal ointment | Medicines & Healthcare Products Regulatory Agency (GB) | MPI, EU: SmPC | |
| GLYCERYL TRINITATE Sublingual tablets | Medicines & Healthcare Products Regulatory Agency (GB) | MPI, EU: SmPC | |
| NITRO-DUR Transdermal patch | FDA, National Drug Code (US) | MPI, US: SPL/Old | |
| NITROLINGUAL Sublingual spray | Medicines & Healthcare Products Regulatory Agency (GB) | MPI, EU: SmPC |
Glyceryl trinitrate is an active ingredient of these brands:
Australia (AU)Austria (AT)Brazil (BR)Canada (CA)Croatia (HR)Cyprus (CY)Ecuador (EC)Estonia (EE)Finland (FI)France (FR)Germany (DE)Hong Kong (HK)Ireland (IE)Israel (IL)Italy (IT)Japan (JP)Lithuania (LT)Malta (MT)Mexico (MX)Netherlands (NL)New Zealand (NZ)Poland (PL)Singapore (SG)
South Africa (ZA)Spain (ES)Tunisia (TN)Turkey (TR)United Kingdom (UK)Note the following: The list of brand names is continuously updated, and thus does not include the total of products circulating worldwide. |
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