Unresponsive congestive heart failure

Active Ingredient: Glyceryl trinitrate

Indication for Glyceryl trinitrate

Population group: only adults (18 years old or older)

Unresponsive congestive heart failure, including that secondary to acute myocardial infarction.

For this indication, competent medicine agencies globally authorize below treatments:

10-100 micrograms/minute

Route of admnistration

Intravenous

Defined daily dose

10 - 100 ug

Dosage regimen

From 10 To 100 ug once every day

Detailed description

The normal dose range is 10-100 micrograms/minute administered as a continuous intravenous infusion with frequent monitoring of blood pressure and heart rate. The infusion should be started at the lower rate and increased cautiously until the desired clinical response is achieved. Other haemodynamic measurements are extremely important in monitoring response to the drug: These may include pulmonary capillary wedge pressure, cardiac output and precordial electrocardiogram depending on the clinical picture.

Active ingredient

Glyceryl trinitrate

Glyceryl trinitrate is a vasodilator and is used for angina of effort. Vasodilation is achieved by the releasing of free redical nitric oxide which activates guanylate cyclase and increases synthesis of guanosine 3′ and 5′-monophosphate with resultant effects on the phosphorylation of proteins in smooth muscle. If taken in excess, its vasodilatory effect can cause headache.

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