Source: Medicines & Healthcare Products Regulatory Agency (GB) Revision Year: 2009 Publisher: Pharmacia Limited, Ramsgate Road, Sandwich, Kent CT13 9NJ, United Kingdom
After administration chloramphenicol is rapidly released from chloramphenicol sodium succinate. Chloramphenicol is active against many gram-positive and gram negative organisms, Spirillae and Rickettsia. It acts by interfering with bacterial protein synthesis. Chloramphenicol is widely distributed in body tissues and fluids and enters the cerebrospinal fluid.
Chloramphenicol sodium succinate, free chloramphenicol and metabolites are excreted in the urine.
After intravenous administration of chloramphenicol succinate every 6 hours elimination half-lives were 4.03 hours for chloramphenicol and 2.65 hours for chloramphenicol succinate. After intravenous chloramphenicol sodium succinate, steady state peak concentrations were reached on average 18.0 minutes after cessation of the infusion.
In infants and children aged 3 days to 16 years the apparent half-life was extremely variable ranging from 1.7 to 12.0 hours.
None stated.
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