Source: Medicines & Healthcare Products Regulatory Agency (GB) Revision Year: 2007 Publisher: Pharma Global Limited Hudson Road Sandycove Co Dublin Ireland
Sodium cromoglycate has neither anti-histaminic or anti-inflammatory activity. Evidence suggests that sodium cromoglycate inhibits the release of mediators of the allergic reaction by stabilising the membranes of sensitised mast cells.
Due to lipid insolubility, sodium cromoglycate is poorly absorbed following administration to the eye. In normal volunteers approximately 0.03% is systemically absorbed. Absorbed sodium cromoglycate is excreted unchanged in the bile and urine.
Trace amounts of sodium cromoglycate have been detected in the aqueous humor of rabbits for up to 24 hours after treatment.
The results of the studies do not add to the information needed by the prescriber, consequently, they are not repeated in the SPC.
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