Rythmodan 100mg Capsules Ref.[2751] Active ingredients: Disopyramide

Source: Medicines & Healthcare Products Regulatory Agency (GB)  Revision Year: 2011 

Therapeutic indications

Rythmodan is used in the treatment of cardiac arrhythmias as follows:

  1. The prevention and treatment of arrhythmias occurring after myocardial infarction.
  2. Maintenance of normal rhythm following electroconversion eg atrial fibrillation, atrial flutter.
  3. Persistent ventricular extrasystoles.
  4. Control of arrhythmias following the use of digitalis or similar glycosides.
  5. Suppression of arrhythmias during surgical procedures eg cardiac catheterisation.
  6. The prevention of paraxysmal supraventricular tachycardia.
  7. Other types of arrhythmias e.g. atrial extrasystoles, Wolff-Parkinson-White Syndrome.

Posology and method of administration

Route of administration

Oral.

300 mg to 800mg daily in divided doses.

Children

Not recommended as insufficient data available.

Elderly

A dose reduction due to reduced renal and hepatic function in the elderly (especially elderly non-smokers) should be considered (see section 4.4)

Overdose

There is no specific antidote for disopyramide. Prostigmine derivatives can be used to treat anticholinergic effects. Symptomatic supportive measures may include: early gastric lavage; administration of a cathartic followed by activated charcoal by mouth or stomach tube; IV administration of isoprenaline, other vasopressors and/or positive inotropic agents; if needed – infusion of lactate and/or magnesium, electro–systolic assistance, cardioversion, insertion of an intra–aortic balloon for counterpulsion and mechanically assisted ventilation. Haemodialysis, haemofiltration or haemoperfusion with activated charcoal has been employed to lower the serum concentrations of the drug.

Shelf life

PVC Blister: 36 months.

Special precautions for storage

Do not store above 25°C.

Nature and contents of container

Sanofi-aventis
One Onslow Street
Guildford
Surrey GU1 4YS
UK

Nature and contents of container

PVC Blister containing 84 capsules.

Special precautions for disposal and other handling

None.

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