Source: FDA, National Drug Code (US) Revision Year: 2021
Hyoscyamine sulfate Injection, USP inhibits specifically the actions of acetylcholine on structures innervated by postganglionic cholinergic nerves and on smooth muscles that respond to acetylcholine but lack cholinergic innervation. These peripheral cholinergic receptors are present in the autonomic effector cells of the smooth muscle, cardiac muscle, the sinoatrial node, the atrioventricular node, and the exocrine glands. It is completely devoid of any action in the autonomic ganglia. Hyoscyamine sulfate Injection, USP inhibits gastrointestinal propulsive motility and decreases gastric acid secretion. Hyoscyamine sulfate Injection, USP also controls excessive pharyngeal, tracheal and bronchial secretions.
Hyoscyamine sulfate Injection, USP disappears rapidly from the blood and is distributed throughout the entire body. The half-life of Hyoscyamine sulfate Injection, USP is 3 ½ hours. Hyoscyamine sulfate Injection, USP is partly hydrolyzed to tropic acid and tropine but the majority of the drug is excreted in the urine unchanged within the first 12 hours. Only traces of this drug are found in breast milk. Hyoscyamine sulfate Injection, USP passes the blood brain barrier and the placental barrier.
No long-term studies in animals have been performed to determine the carcinogenic, mutagenic or impairment of fertility potential of Hyoscyamine sulfate Injection, USP.
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