Source: Health Products Regulatory Authority (ZA) Revision Year: 2017 Publisher: PHARMACARE LIMITED, Healthcare Park, Woodlands Drive, Woodmead 2191
TREPILINE is a tricyclic antidepressant indicated in the treatment of patients 18 years and older with depression.
Initially 75 mg to 150 mg daily in divided doses.
Maintenance dose is 50 mg to 100 mg daily in divided doses.
See SIDE EFFECTS.
Overdosage and poisoning may be characterised by central nervous system depression or excitation, severe anticholinergic effects and cardiotoxicity. The following symptoms and signs are characteristic of acute overdosage: drowsiness, restlessness, ataxia, stupor, coma, pyrexia, palpitations, tachycardia, cardiac dysrhythmias, hypotension, and in severe cases, respiratory depression. Epileptiform seizures may occur. Mixed poisoning with other central nervous system depressants is not uncommon.
Treatment is symptomatic and supportive.
Store at or below 25°C.
Protect from light and moisture.
KEEP OUT OF REACH OF CHILDREN.
TREPILINE 10: Packs of 100 and 500 tablets in white polypropylene securitainers together with a foam insert/rayon and professional information which is sealed with white, low density polyethylene securitainer caps.
Packs of 28 tablets into metallised patient ready packs which are sealed with lay-flat zips after filling and packed into polyethylene bags.
TREPILINE 25: Packs of 100 and 500 tablets in white polypropylene securitainers together with a foam insert/rayon and professional information which is sealed with white low density polyethylene securitainer caps.
Packs of 28 and 84 tablets into metallised patient ready packs which are sealed with lay-flat zips after filling and packed into polyethylene bags.
Not all packs and pack sizes are necessarily marketed.
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