Chemical formula: C₂₀H₂₃N Molecular mass: 277.403 g/mol PubChem compound: 2160
Amitriptyline is a tricyclic antidepressant and an analgesic. It prevents the re-uptake, and hence the inactivation of noradrenaline and serotonin at nerve terminals. Reuptake prevention of these monoamine neurotransmitters potentiate their action in the brain. This appears to be associated with the antidepressant activity.
This medicinal substance has been classified in the anatomical therapeutic chemical (ATC) classification according to its main therapeutic use as follows:
| ATC code | Group title | Classification |
|---|---|---|
| N06AA09 | Amitriptyline | N Nervous system → N06 Psychoanaleptics → N06A Antidepressants → N06AA Non-selective monoamine reuptake inhibitors |
Competent medicine agencies globally have authorized commercialization of this active ingredient according to these medication package inserts (MPIs):
| Title | Information Source | Document Type | |
|---|---|---|---|
| AMITRIPTYLINE Film-coated tablet | Medicines & Healthcare Products Regulatory Agency (GB) | MPI, EU: SmPC |
Amitriptyline is an active ingredient of these brands:
United States (US)
Albania (AL)
Austria (AT)
Brazil (BR)Canada (CA)
Cyprus (CY)
Ecuador (EC)Estonia (EE)
Finland (FI)
Germany (DE)
Hong Kong (HK)Ireland (IE)
Italy (IT)
Japan (JP)
Malta (MT)
Mexico (MX)
New Zealand (NZ)
Singapore (SG)
South Africa (ZA)Spain (ES)Tunisia (TN)
Turkey (TR)
Note the following: The list of brand names is continuously updated, and thus does not include the total of products circulating worldwide. |
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