AMILORETIC Tablet Ref.[51293] Active ingredients: Amiloride Hydrochlorothiazide

Category and Class: A 18.1 Diuretics
Pharmacotherapeutic group: Medicines acting on reno- urinary and genital system
ATC code: C03AX01

Mechanism of action

Hydrochlorothiazide and amiloride are both oral diuretics which act by reducing reabsorption of electrolytes from the renal tubules thereby increasing the excretion of sodium and chloride ions and consequently of water.

Hydrochlorothiazide also increases the excretion of potassium ions while amiloride has the opposite effect and has been found to diminish the kaluretic effects of other diuretics i.e. hydrochlorothiazide in this combination.

Hydrochlorothiazide slightly increases the bicarbonate excretion without appreciable alteration to the acid-base balance of the pH of the urine. It has an anti-hypertensive effect and enhances the action of other hypotensive medicines.

Due to its amiloride component, the urinary excretion of magnesium is less with AMILORETIC than with a thiazide or loop diuretic used alone. The onset of the diuretic action of AMILORETIC is within 2 hours, and this action may still be evident for approximately 24 hours.