Source: Health Products Regulatory Authority (ZA) Revision Year: 2022 Publisher: Ranbaxy Pharmaceuticals (Pty) Ltd, a Sun Pharma Company, 14 Lautre Road, Stormill Ext 1, Roodepoort, 1724, South Africa
A 5.7.1 Antihistaminics
Levocetirizine, the (R) enantiomer of cetirizine, is a histamine H1 receptor antagonist.
Levocetirizine is absorbed following oral administration.
Levocetirizine is 90% bound to human plasma proteins. Peak plasma concentrations are achieved 0,9 hour after administration of the oral tablet.
The extent of metabolism of levocetirizine in humans is less than 14 % of the dose.
The plasma half-life in adults is about 8 hours. The main route of excretion is via urine, accounting for approximately 85% of the dose. Excretion via the faeces accounts for only 13% of the dose.
Plasma levels are linearly related between 2,5 mg and 20 mg.
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