COVERSYL PLUS Tablet Ref.[50551] Active ingredients: Indapamide Perindopril

Following oral administration the absorption of perindopril is rapid (peak concentration within 1 hour), and relatively complete (plasma-availability above 75%). The peak concentration of perindoprilat, the active metabolite, is reached within 3 to 4 hours and peak pharmacological activity is obtained within 4 to 6 hours.

In terms of trough versus peak blood pressure effect, the trough effect ranges between 75–100% of peak effects.

Perindopril and perindoprilat both have a low volume of distribution and plasma protein binding is weak. Perindoprilat binds to angiotensin converting enzyme at both plasma and tissue levels. Apart from active perindoprilat, perindopril gives rise to 5 metabolites, all of which are inactive. Perindopril is eliminated in the urine and the half-life of its free fraction is approximately one hour. Breakdown of the bond between perindoprilat and the angiotensin-converting enzyme leads to a pharmacodynamic half-life of about 25 hours.

Indapamide, [N-(3-sulphamoyl-4-chlorobenzamido) 2-methyl indoline] is an indole derivative of chlorosulphonamide with an antihypertensive action. It has an extrarenal antihypertensive action resulting in a decrease in vascular hyper-reactivity and a reduction in total peripheral and arteriolar resistance. This action is thought to be due to the inhibition of transmembrane ionic influx, essentially calcic, and the stimulation of synthesis of the vasodilatory hypotensive prostaglandin PGE2.

There is also a direct renal diuretic action.

Prolonged use of indapamide has been shown to be associated with a reduction in left ventricular mass in hypertensive patients.