Source: Medicines & Healthcare Products Regulatory Agency (GB) Revision Year: 2016 Publisher: McNeil Products Limited, Foundation Park, Roxborough Way, Maidenhead, Berkshire, SL6 3UG, United Kingdom
Pharmacotherapeutic classification: Antifungals for dermatological/topical use; imidazole derivative
ATC code: D01AC02
Miconazole nitrate is an imidazole antifungal agent and may act by interfering with the permeability of the fungal cell membrane. It possesses a wide antifungal spectrum and has some antibacterial activity.
There is little absorption through skin or mucous membranes when miconazole nitrate is applied topically.
Absorbed miconazole is bound to plasma proteins (88.2%) and red blood cells (10.6%).
The small amount of miconazole that is absorbed is eliminated predominantly in faeces as both unchanged drug and metabolites.
Preclinical data reveal no special hazard for humans based on conventional studies of local irritation, single and repeated dose toxicity, genotoxicity, and toxicity to reproduction.
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