Chemical formula: C₁₈H₁₄Cl₄N₂O Molecular mass: 416.129 g/mol PubChem compound: 4189
Miconazole possesses an antifungal activity against the common dermatophytes and yeasts as well as an antibacterial activity against certain gram-positive bacilli and cocci. Its activity is based on the inhibition of the ergosterol biosynthesis in fungi and the change in the composition of the lipid components in the membrane, resulting in fungal cell necrosis.
This medicinal substance has been classified in the anatomical therapeutic chemical (ATC) classification according to its main therapeutic use as follows:
| ATC code | Group title | Classification |
|---|---|---|
| A01AB09 | Miconazole | A Alimentary tract and metabolism → A01 Stomatological preparations → A01A Stomatological preparations → A01AB Antiinfectives and antiseptics for local oral treatment |
| A07AC01 | Miconazole | A Alimentary tract and metabolism → A07 Antidiarrheals, intestinal antiinflammatory/antiinfective agents → A07A Intestinal antiinfectives → A07AC Imidazole derivatives |
| D01AC02 | Miconazole | D Dermatologicals → D01 Antifungals for dermatological use → D01A Antifungals for topical use → D01AC Imidazole and triazole derivatives |
| G01AF04 | Miconazole | G Genito urinary system and sex hormones → G01 Gynecological antiinfectives and antiseptics → G01A ANTIINFECTIVES AND ANTISEPTICS, EXCL. COMBINATIONS WITH CORTICOSTEROIDS → G01AF Imidazole derivatives |
| J02AB01 | Miconazole | J Antiinfectives for systemic use → J02 Antimycotics for systemic use → J02A Antimycotics for systemic use → J02AB Imidazole derivatives |
| S02AA13 | Miconazole | S Sensory organs → S02 Otologicals → S02A Antiinfectives → S02AA Antiinfectives |
Competent medicine agencies globally have authorized commercialization of this active ingredient according to these medication package inserts (MPIs):
| Title | Information Source | Document Type | |
|---|---|---|---|
| GYNO-DAKTARIN Vaginal cream | Medicines & Healthcare Products Regulatory Agency (GB) | MPI, EU: SmPC | |
| DAKTARIN Oral gel | Medicines & Healthcare Products Regulatory Agency (GB) | MPI, EU: SmPC | |
| DAKTARIN INTENSIV Cream | Medicines & Healthcare Products Regulatory Agency (GB) | MPI, EU: SmPC | |
| DAKTARIN Cream | Medicines & Healthcare Products Regulatory Agency (GB) | MPI, EU: SmPC |
Miconazole is an active ingredient of these brands:
United States (US)
Australia (AU)
Austria (AT)Brazil (BR)
Canada (CA)
Croatia (HR)
Cyprus (CY)
Ecuador (EC)
Finland (FI)
Germany (DE)
Hong Kong (HK)
Ireland (IE)
Israel (IL)Malta (MT)
Mexico (MX)
Netherlands (NL)
New Zealand (NZ)Nigeria (NG)
Poland (PL)
Singapore (SG)
South Africa (ZA)
Turkey (TR)
United Kingdom (UK)
Note the following: The list of brand names is continuously updated, and thus does not include the total of products circulating worldwide. |
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