ESTREVA Gel Ref.[50461] Active ingredients: Estradiol

Estreva gel is presented in tube-bottles with dosing pumps.

Each dose delivers 0.5 g of gel, ie 0.5 mg of estradiol.

The average dose is 1.5 g of gel per day, i.e. 3 doses, for 24 to 28 days.

The dosage can be adapted to particular needs, or any residual estrogen production and individual pharmacokinetic characteristics.

The dosage may be readapted after 2 or 3 treatment cycles, depending on the clinical symptomatology, in other words:

The dose can be reduced should symptoms of hyperestrogenia, such as painful breasts, abdominal pelvic swelling, anxiety, tension, aggressiveness occur.

The dose can be increased should hypoestrogenic symptoms occur, such as persistance of hot flushes, vaginal dryness, headaches and problems with sleeping, asthenia, tendency for depression.

It is highly recommended that a progestogen be combined for the last 12 to 15 days of use of estradiol gel.

The patient applies the gel onto clean skin, preferably after washing in the morning or evening, on the abdomen, thighs, arms, shoulder, with the exception of the breasts. The gel should not be applied to the mucosa. Massage is of no use but it is recommended that subjects wait 2 minutesbefore putting on clothes. The gel does not cause staining.

The effects of an overdose are usually a feeling of tightness in the breast, abdominopelvic swelling, anxiety, tension, aggressiveness (see posology and method of administration).

Store in a cool place (<25°C).