MEDOTRAMOL Film-coated tablet Ref.[50520] Active ingredients: Paracetamol Tramadol Tramadol and Paracetamol

Paracetamol is a medication used to treat pain and fever. It does appear to selectively inhibit COX activities in the brain, which may contribute to its ability to treat fever and pain.

Tramadol is a centrally acting opioid analgesic. It is a non selective pure agonist at μ-, δ- and κ-opioid receptors with a higher affinity for the μ-receptor. Other mechanisms which may contribute to its analgesic effect are inhibition of neuronal reuptake of noradrenaline and enhancement of serotonin release. Tramadol has an antitussive effect. In contrast to morphine, analgesic doses of tramadol over a wide range have no respiratory depressant effect.

Tramadol is an opioid analgesic that acts on the central nervous system. Tramadol is a pure non selective agonists of the µ, δ, and κ opioid receptors with a higher affinity for the µ receptors. Tramadol has an antitussive effect. The precise mechanism of the analgesic properties of paracetamol is unknown and may involve central and peripheral effects. Tramadol/paracetamol is positioned as a step II analgesic in the WHO pain ladder and should be utilised accordingly by the physician.