Chemical formula: C₁₆H₂₅NO₂ Molecular mass: 263.381 g/mol PubChem compound: 33741
Tramadol is a centrally acting opioid analgesic. It is a non selective pure agonist at μ-, δ- and κ-opioid receptors with a higher affinity for the μ-receptor. Other mechanisms which may contribute to its analgesic effect are inhibition of neuronal reuptake of noradrenaline and enhancement of serotonin release. Tramadol has an antitussive effect. In contrast to morphine, analgesic doses of tramadol over a wide range have no respiratory depressant effect.
This medicinal substance has been classified in the anatomical therapeutic chemical (ATC) classification according to its main therapeutic use as follows:
| ATC code | Group title | Classification |
|---|---|---|
| N02AX02 | Tramadol | N Nervous system → N02 Analgesics → N02A Opioids → N02AX Other opioids |
Competent medicine agencies globally have authorized commercialization of this active ingredient according to these medication package inserts (MPIs):
| Title | Information Source | Document Type | |
|---|---|---|---|
| TRAMADOL HYDROCHLORIDE HAMELN PHARMA Solution for injection or infusion | Medicines & Healthcare Products Regulatory Agency (GB) | MPI, EU: SmPC | |
| TRAMAL Capsule, Solution for injection, Tablet | Medicines and Medical Devices Safety Authority (NZ) | MPI, EU: SmPC | |
| TRAMADOL Capsule, hard | Medicines & Healthcare Products Regulatory Agency (GB) | MPI, EU: SmPC | |
| ULTRAM Coated tablet | FDA, National Drug Code (US) | MPI, US: SPL/PLR | |
| TRAMADOL HYDROCHLORIDE KRKA Prolonged-release tablet | Medicines & Healthcare Products Regulatory Agency (GB) | MPI, EU: SmPC |
Tramadol is an active ingredient of these brands:
United States (US)Australia (AU)Austria (AT)
Brazil (BR)
Canada (CA)Croatia (HR)
Cyprus (CY)
Ecuador (EC)
Estonia (EE)
Finland (FI)
France (FR)
Germany (DE)
Hong Kong (HK)
Ireland (IE)
Israel (IL)Japan (JP)Lithuania (LT)Malta (MT)Mexico (MX)
Netherlands (NL)
Nigeria (NG)
Poland (PL)
Romania (RO)Singapore (SG)
South Africa (ZA)
Spain (ES)
Tunisia (TN)
Turkey (TR)
United Kingdom (UK)
Note the following: The list of brand names is continuously updated, and thus does not include the total of products circulating worldwide. |
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