Source: FDA, National Drug Code (US) Revision Year: 2019
MS CONTIN (morphine sulfate extended-release tablets) is for oral use and contains morphine sulfate, an opioid agonist.
Each tablet contains the following inactive ingredients common to all strengths: cetostearyl alcohol, hydroxyethyl cellulose, hypromellose, magnesium stearate, polyethylene glycol, talc, and titanium dioxide.
The tablet strengths describe the amount of morphine per tablet as the pentahydrated sulfate salt (morphine sulfate).
The 15 mg tablets also contain: FD&C Blue No. 2, lactose, polysorbate 80
The 30 mg tablets also contain: D&C Red No. 7, FD&C Blue No. 1, lactose, polysorbate 80
The 60 mg tablets also contain: D&C Red No. 30, D&C Yellow No. 10, hydroxypropyl cellulose, lactose
The 100 mg tablets also contain: black iron oxide
The 200 mg tablets also contain: D&C Yellow No. 10, FD&C Blue No. 1, hydroxypropyl cellulose
Morphine sulfate is an odorless, white, crystalline powder with a bitter taste. It has a solubility of 1 in 21 parts of water and 1 in 1000 parts of alcohol, but is practically insoluble in chloroform or ether. The octanol: water partition coefficient of morphine is 1.42 at physiologic pH and the pKb is 7.9 for the tertiary nitrogen (mostly ionized at pH 7.4). Its molecular weight is 758.83 and its structural formula is:
| Dosage Forms and Strengths |
|---|
|
MS CONTIN (morphine sulfate extended-release tablets) 15 mg: Round, blue-colored, film-coated tablets bearing the symbol PF on one side and M 15 on the other. MS CONTIN (morphine sulfate extended-release tablets) 30 mg: Round, lavender-colored, film-coated tablets bearing the symbol PF on one side and M 30 on the other. MS CONTIN (morphine sulfate extended-release tablets) 60 mg: Round, orange-colored, film-coated tablets bearing the symbol PF on one side and M 60 on the other. MS CONTIN (morphine sulfate extended-release tablets) 100 mg: Round, gray-colored, film-coated tablets bearing the symbol PF on one side and 100 on the other. MS CONTIN (morphine sulfate extended-release tablets) 200 mg: Capsule-shaped, green-colored, film-coated tablets bearing the symbol PF on one side and M 200 on the other. |
| How Supplied | ||||||||||
|---|---|---|---|---|---|---|---|---|---|---|
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MS CONTIN (morphine sulfate extended-release tablets) are supplied as follows: 15 mg: round, blue-colored, film-coated tablets bearing the symbol PF on one side and M 15 on the other.
30 mg: round, lavender-colored, film-coated tablets bearing the symbol PF on one side and M 30 on the other.
60 mg: round, orange-colored, film-coated tablets bearing the symbol PF on one side and M 60 on the other.
100 mg: round, gray-colored, film-coated tablets bearing the symbol PF on one side and 100 on the other.
200 mg: capsule-shaped, green-colored, film-coated tablets bearing the symbol PF on one side and M 200 on the other.
Manufactured by: Purdue Pharma L.P., Stamford, CT 06901-3431 Marketed by: Rhodes Pharmaceuticals L.P., Coventry, RI 02816 |
| Drug | Countries | |
|---|---|---|
| MS CONTIN | Australia, Canada, Japan, Malta, Netherlands, United States |
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