Source: Marketing Authorisation Holder Revision Year: 2013
URIMAX D Tablets (Tamsulosin hydrochloride + Dutasteride).
| Pharmaceutical Form |
|---|
|
Oral tablet. |
Each film-coated tablet contains:
Tamsulosin Hydrochloride: 0.4 mg (as modified-release tablets)
Dutasteride: 0.5 mg
The symptoms associated with benign prostatic hyperplasia (BPH) are related to bladder outlet obstruction, which is comprised of two underlying components: static and dynamic. The static component is related to an increase in the prostate size, caused, in part, by a proliferation of smooth muscle cells in the prostatic stroma. The dynamic component is a function of an increase in smooth muscle tone in the prostate and bladder neck, leading to constriction of the bladder outlet.
Tamsulosin hydrochloride, a selective alpha1A-adrenoceptor blocking agent, exhibits selectivity for alpha1A-receptors in the human prostate. Tamsulosin hydrochloride acts by relaxing smooth muscles of the bladder neck, prostatic capsule and prostatic urethra.
Dutasteride is a synthetic 4-azasteroid compound that is a selective inhibitor of both the type I and type II isoforms of steroid 5 alpha-reductase, an intracellular enzyme that converts testosterone to 5 alpha-dihydrotestosterone (DHT). DHT is the androgen primarily responsible for the initial development and subsequent enlargement of the prostate gland.
| Active Ingredient | Description | |
|---|---|---|
| Dutasteride |
Dutasteride reduces circulating levels of dihydrotestosterone (DHT) by inhibiting both type 1 and type 2, 5α-reductase isoenzymes which are responsible for the conversion of testosterone to DHT. |
|
| Tamsulosin |
Tamsulosin binds selectively and competitively to post-synaptic α1-adrenoreceptors, prevailingly their subtypes designated α1A and α1D. Thus relaxation of smooth muscles of the prostate and urethra is achieved, which leads to a reduction of tonus and an improvement of the urinary flow. |
| List of Excipients |
|---|
|
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URIMAX D Tablets: Pack of 10 tablets.
| Drug | Countries | |
|---|---|---|
| UROMAX CO | South Africa |
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